Dual Gold-Catalyzed Cycloaromatization of Unconjugated (E)-Enediynes
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Zamani, Farzad
Babaahmadi, Rasool
Yates, Brian F.
Gardiner, Michael G.
Ariafard, Alireza
Pyne, Stephen G.
Hyland, Christopher J.T.
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Abstract
A synthesis of unconjugated (E)-enediynes from allenyl amino alcohols is reported and their gold-catalyzed cascade cycloaromatization to a broad range of enantioenriched substituted isoindolinones has been developed. Experimental and computational studies support the reaction proceeding via a dual-gold σ,π-activation mode, involving a key gold-vinylidene- and allenyl-gold-containing intermediate.
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Angewandte Chemie - International Edition
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