Nanoparticles mimicking viral surface topography for enhanced cellular delivery

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Niu, Yuting
Yu, Meihua
Hartono, Sandy B.
Yang, Jie
Xu, Hongyi
Zhang, Hongwei
Zhang, Jun
Zou, Jin
Dexter, Annette
Gu, Wenyi

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Novel silica nanoparticles mimicking virus surface topography are prepared. It is demonstrated that increases in nanoscale surface roughness promote both binding of biomolecules and cellular uptake; thus, the cellular delivery efficiency is significantly increased (scale bars 20â€...μm).

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