CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population
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Wray, Bradley N.
Stankovich, Jim
Whittock, Lucy
Dwyer, Terence
Ponsonby, Anne Louise
van der Mei, Ingrid A.F.
Taylor, Bruce
Dickinson, Joanne
Foote, Simon
McMorran, Brendan J.
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Abstract
Multiple sclerosis (MS) is a chronic autoimmune disorder that causes inflammatory demyelination and axonal damage in the central nervous system (CNS). We have investigated whether the A49G single nucleotide polymorphism (SNP) genotype of the CTLA-4 gene influenced the development of MS in Southern Australians as well as the interaction of this SNP with the DRB1*15 haplotype. There were no significant (P < 0.05) associations between the A49G genotype and risk of MS, either before or after stratification for presence of the DR15 haplotype.
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Journal of Neuroimmunology
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