Supramolecular Encapsulation and Bioactivity Modulation of a Halonium Ion by Cucurbit [n] uril (n = 7, 8)
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Yin, Hang
Huang, Qiaoxian
Zhao, Wenwen
Bardelang, David
Siri, Didier
Chen, Xiuping
Lee, Simon M.Y.
Wang, Ruibing
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Abstract
This is the first time that cucurbit[7]uril and cucurbit[8]uril have been demonstrated to serve as synthetic receptors for a halonium guest species, diphenyleneiodonium, modulating its bioactivities and alleviating its cardiotoxicity, which further expands the onium family of guest molecules for the cucurbit[n]uril family and provides new insights for halonium-cucurbit[n]uril host-guest chemistry and its potential applications in pharmaceutical chemistry.
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Journal of Organic Chemistry
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