Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer
Date
Authors
Barros-Silva, João D.
Linn, Douglas E.
Steiner, Ivana
Guo, Guoji
Ali, Adnan
Pakula, Hubert
Ashton, Garry
Peset, Isabel
Brown, Michael
Clarke, Noel W.
Journal Title
Journal ISSN
Volume Title
Publisher
Access Statement
Abstract
To address the identity of castration-resistant prostate cells in vivo, Barros-Silva et al. coupled single-cell analysis with organoid culture and in situ lineage tracing. They identify LY6D as a progenitor marker that liaises intrinsically castration-resistant luminal cells and castration-resistant prostate tumor growth.
Description
Citation
Collections
Source
Cell Reports
Type
Book Title
Entity type
Publication