Shear-Thinning and Designable Responsive Supramolecular DNA Hydrogels Based on Chemically Branched DNA

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dc.contributor.authorYang, Boen
dc.contributor.authorZhao, Zhihanen
dc.contributor.authorPan, Yufanen
dc.contributor.authorXie, Jiayinen
dc.contributor.authorZhou, Binien
dc.contributor.authorLi, Yujieen
dc.contributor.authorDong, Yuanchenen
dc.contributor.authorLiu, Dongshengen
dc.date.accessioned2026-01-01T18:41:19Z
dc.date.available2026-01-01T18:41:19Z
dc.date.issued2021-10-11en
dc.description.abstractA novel supramolecular DNA hydrogel system was designed based on a directly synthesized chemically branched DNA. For the hydrogel formation, a self-dimer DNA with two sticky ends was designed as the linker to induce the gelation of B-Y. By programing the linker sequence, thermal and metal-ion responsiveness could be introduced into this hydrogel system. This supramolecular DNA hydrogel shows shear-thinning, designable responsiveness, and good biocompatibility, which will simplify the hydrogel composition and preparation process of the supramolecular DNA hydrogel and accelerate its biomedical applications.en
dc.description.sponsorshipThe authors thank the National Natural Science Foundation of China (21821001, 21890731, 21971248, 21534007, and 21890730) and Natural Science Foundation of Beijing Municipality (Z180016) for financial support.en
dc.description.statusPeer-revieweden
dc.format.extent9en
dc.identifier.issn1944-8244en
dc.identifier.otherPubMed:34633793en
dc.identifier.otherORCID:/0000-0002-8638-0061/work/177709126en
dc.identifier.scopus85117782478en
dc.identifier.urihttps://hdl.handle.net/1885/733801968
dc.language.isoenen
dc.rightsPublisher Copyright: © 2021 American Chemical Society.en
dc.sourceACS Applied Materials and Interfacesen
dc.subject3D cell cultureen
dc.subjectbranched DNAen
dc.subjectshear-thinning propertyen
dc.subjectstimuli-responsive materialen
dc.subjectsupramolecular DNA hydrogelen
dc.titleShear-Thinning and Designable Responsive Supramolecular DNA Hydrogels Based on Chemically Branched DNAen
dc.typeJournal articleen
dspace.entity.typePublicationen
local.bibliographicCitation.lastpage48422en
local.bibliographicCitation.startpage48414en
local.contributor.affiliationYang, Bo; Tsinghua Universityen
local.contributor.affiliationZhao, Zhihan; Tsinghua Universityen
local.contributor.affiliationPan, Yufan; Tsinghua Universityen
local.contributor.affiliationXie, Jiayin; Tsinghua Universityen
local.contributor.affiliationZhou, Bini; Tsinghua Universityen
local.contributor.affiliationLi, Yujie; Tsinghua Universityen
local.contributor.affiliationDong, Yuanchen; CAS - Institute of Chemistryen
local.contributor.affiliationLiu, Dongsheng; Tsinghua Universityen
local.identifier.citationvolume13en
local.identifier.doi10.1021/acsami.1c15494en
local.identifier.pure45eb2a77-19ec-45d1-9754-ffe8eb5377d1en
local.identifier.urlhttps://www.scopus.com/pages/publications/85117782478en
local.type.statusPublisheden

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