Protein evolution as a complex system
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Gall, Barnabas
Pulsford, Sacha B.
Matthews, Dana S.
Spence, Matthew A.
Kaczmarski, Joe A.
Chen, John
Sandhu, Mahakaran
Stone, Eric A.
Nichols, James
Jackson, Colin J.
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Abstract
Viewing protein evolution through the lens of complex systems theory may offer new insights into the principles driving biological adaptation. In this Comment we explore how characteristics such as sensitivity to initial conditions and self-organization are observed in protein evolution and discuss how machine learning can help model these dynamics to guide protein engineering.
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Nature Chemical Biology
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