Gold-catalyzed domino cyclization-alkynylation reactions with EBX reagents

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Ghari, Hossein
Li, Yifan
Roohzadeh, Roohollah
Caramenti, Paola
Waser, Jerome
Ariafard, Alireza

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Gold-catalyzed domino processes constitute a useful alternative to C-H functionalization for the synthesis of functionalized (hetero)arenes. Herein, we report computational studies on the gold-catalyzed cyclization alkynylation of keto-allenes with ethynylbenziodoxole (EBX) reagents, which identified a gold(i) picolinate complex as the active catalyst, giving the first mechanistic insights into this transformation.

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Dalton Transactions

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