Constructing Tissuelike Complex Structures Using Cell-Laden DNA Hydrogel Bricks
| dc.contributor.author | Wang, Yijie | en |
| dc.contributor.author | Shao, Yu | en |
| dc.contributor.author | Ma, Xiaozhou | en |
| dc.contributor.author | Zhou, Bini | en |
| dc.contributor.author | Faulkner-Jones, Alan | en |
| dc.contributor.author | Shu, Wenmiao | en |
| dc.contributor.author | Liu, Dongsheng | en |
| dc.date.accessioned | 2026-01-01T18:41:27Z | |
| dc.date.available | 2026-01-01T18:41:27Z | |
| dc.date.issued | 2017-04-12 | en |
| dc.description.abstract | Tissue engineering has long been a challenge because of the difficulty of addressing the requirements that such an engineered tissue must meet. In this paper, we developed a new “brick-to-wall” based on unique properties of DNA supramolecular hydrogels to fabricate three-dimensional (3D) tissuelike structures: different cell types are encapsulated in DNA hydrogel bricks which are then combined to build 3D structures. Signal responsiveness of cells through the DNA gels was evaluated and it was discovered that the gel permits cell migration in 3D. The results demonstrated that this technology is convenient, effective and reliable for cell manipulation, and we believe that it will benefit artificial tissue fabrication and future large-scale production. | en |
| dc.description.sponsorship | We thank Associate Professor Mou’s group in Lanzhou University for their assistant in cell culture and related experiments. We also thank National Basic Research Program of China (973 program, No. 2013CB932803), the National Natural Science Foundation of China (No. 21534007, 91427302, 21421064). AFJ and WS acknowledge the funding support from UK’s EPSRC (EP/M506837/1, EP/P511420/1). | en |
| dc.description.status | Peer-reviewed | en |
| dc.format.extent | 5 | en |
| dc.identifier.issn | 1944-8244 | en |
| dc.identifier.other | PubMed:28300395 | en |
| dc.identifier.other | ORCID:/0000-0002-8638-0061/work/177709136 | en |
| dc.identifier.scopus | 85017478848 | en |
| dc.identifier.uri | https://hdl.handle.net/1885/733801989 | |
| dc.language.iso | en | en |
| dc.rights | Publisher Copyright: © 2017 American Chemical Society. | en |
| dc.source | ACS Applied Materials and Interfaces | en |
| dc.subject | cell arrangements | en |
| dc.subject | cell migration | en |
| dc.subject | DNA hydrogel | en |
| dc.subject | self-healing | en |
| dc.subject | supramolecular | en |
| dc.subject | tissue engineering | en |
| dc.title | Constructing Tissuelike Complex Structures Using Cell-Laden DNA Hydrogel Bricks | en |
| dc.type | Journal article | en |
| dspace.entity.type | Publication | en |
| local.bibliographicCitation.lastpage | 12315 | en |
| local.bibliographicCitation.startpage | 12311 | en |
| local.contributor.affiliation | Wang, Yijie; Tsinghua University | en |
| local.contributor.affiliation | Shao, Yu; Tsinghua University | en |
| local.contributor.affiliation | Ma, Xiaozhou; Lanzhou University | en |
| local.contributor.affiliation | Zhou, Bini; Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology | en |
| local.contributor.affiliation | Faulkner-Jones, Alan; University of Strathclyde | en |
| local.contributor.affiliation | Shu, Wenmiao; University of Strathclyde | en |
| local.contributor.affiliation | Liu, Dongsheng; Tsinghua University | en |
| local.identifier.citationvolume | 9 | en |
| local.identifier.doi | 10.1021/acsami.7b01604 | en |
| local.identifier.pure | 7e121cc8-c350-471e-b7f2-df1a36ae5759 | en |
| local.identifier.url | https://www.scopus.com/pages/publications/85017478848 | en |
| local.type.status | Published | en |