Quantitative urinary excretion of unmetabolised N(τ)-[Me-1C]methylhistidine by the common ringtail possum (Pseudocheirus peregrinus) marsupialia
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Watson, Shelley
Foley, William J.
McLean, Stuart
Brandon, Susan
Davies, Noel W.
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Six common ringtail possums (Pseudocheirus peregrinus) were intravenously injected with a standard dose of radioactive 3-Methylhistidine (N(τ)-[Me-14C]MeH). The dose was rapidly and quantitatively excreted by the possums. More than 90% of radioactivity was recovered within 3 days. Thin layer chromatography and mass spectroscopy showed that 97% of recovered radioactivity was associated with unmetabolised N(τ)-[Me14C]MeH. These data satisfy two key requirements for the validity of urinary 3-Methylhistidine (N(τ-)3MeH) excretion as an index of muscle protein catabolism.
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Comparative Biochemistry and Physiology - A Physiology
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