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Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target
Author(s) | de Villiers, Marianne; Spry, Christina; Macuamule, Cristiano, et al |
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Type | Journal article |
Date Published | 2017 |
Date Created | - |
Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway
Author(s) | Fletcher, Sabine; Lucantoni, Leonardo; Sykes, Melissa L., et al |
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Type | Journal article |
Date Published | 17-Nov-2016 |
Date Created | - |
Exploring Heteroaromatic Rings as a Replacement for the Labile Amide of Antiplasmodial Pantothenamides
Author(s) | Guan, Jinming; Spry, Christina; Tjhin, Erick, et al |
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Type | Journal article |
Date Published | 2021 |
Date Created | - |
The key glycolytic enzyme phosphofructokinase is involved in resistance to antiplasmodial glycosides
Author(s) | Fisher, Gillian M.; Cobbold, Simon A.; Jezewski, Andrew, et al |
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Type | Journal article |
Date Published | 2020 |
Date Created | - |
Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues
Author(s) | Tjhin, Erick; Spry, Christina; Sewell, Alan L, et al |
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Type | Journal article |
Date Published | 2018 |
Date Created | - |
A novel heteromeric pantothenate kinase complex in apicomplexan parasites
Author(s) | Tjhin, Erick; Howieson, Vanessa; Spry, Christina, et al |
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Type | Journal article |
Date Published | 29-Jul-2021 |
Date Created | - |
Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801
Author(s) | Domingo, Riyad; van der Westhuyzen, Renier; Hamann, Anton R., et al |
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Type | Journal article |
Date Published | 2019 |
Date Created | - |
Structure-Activity Relationships of Antiplasmodial Pantothenamide Analogues Reveal a New Way by Which Triazoles Mimic Amide Bonds
Author(s) | Guan, Jinming; Tjhin, Erick; Howieson, Vanessa, et al |
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Type | Journal article |
Date Published | 2018 |
Date Created | - |
Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity
Author(s) | Chan, Alex H.Y.; Fathoni, Imam; Ho, Terence C.S, et al |
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Type | Journal article |
Date Published | 2022 |
Date Created | - |
Toward a Stable and Potent Coenzyme A-Targeting Antiplasmodial Agent: Structure-Activity Relationship Studies of N-Phenethyl-α-methyl-pantothenamide
Author(s) | Spry, Christina; Barnard, Leanne; Kok, Michelle, et al |
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Type | Journal article |
Date Published | 2020 |
Date Created | - |
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