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Showing results 2 to 21 of 38
01_Chan_A_functional_genetic_screen_2020.pdf.jpg

A functional genetic screen defines the AKT-induced senescence signaling network

Author(s)Chan, Keefe; Blake, Shaun; Zhu, Haoran, et al
TypeJournal article
Date Published2020
Date Created-

A new window on cancer therapy? Targeting the nucleolus and ribosome biogenesis using the small molecule inhibitor of polymerase I transcription, CX-5461

Author(s)Harrison, Simon J; George, Amee; Hannan, Ross
TypeJournal article
Date Published12-Sep-2015
Date Created-

Abstract A24: A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer

Author(s)Yan, Shunfei; Chan, Keefe; Simpson, Kaylene J., et al
TypeJournal article
Date Published2017
Date Created-

Abstract B23: Inhibition of ribosomal RNA synthesis as a new therapeutic approach to treat advanced prostate cancer

Author(s)Rebello, Richard J; Kusnadi, Eric P.; Cameron, Donald, et al
TypeJournal article
Date Published2017
Date Created-

Abstract IA10: Drugging the ribosome at the level of synthesis and translation to treat solid and hematologic cancers

Author(s)Hannan, Ross; Hein, Nadine; Hannan, Kate, et al
TypeConference paper
Date Published2017
Date Created-

Abstract PR13:Inhibition of RNA polymerase I transcription activates targeted DNA damage response and enhances the efficacy of PARP inhibitors in high-grade ovarian cancer

Author(s)Sanij, Elaine; Hannan, Katherine; Xuan, Jiachen, et al
TypeJournal article
Date Published2020
Date Created-

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Author(s)Hung, Sandy S.-C.; Lesmana, Analie; Peck, Abigail, et al
TypeJournal article
Date Published2017
Date Created-
01_Diesch_Changes_in_long-range_2019.pdf.jpg

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation

Author(s)Diesch, Jeannine; Bywater, Megan J.; Sanij, Elaine, et al
TypeJournal article
Date Published28-Jan-2019
Date Created-
Cohesin mutations.pdf.jpg

Cohesin mutations are synthetic lethal with stimulation of WNT signaling

Author(s)Chin, Chue Vin; Antony, Jisha; Ketharnathan, Sarada, et al
TypeJournal article
Date Published2020
Date Created-

CX-5461 sensitizes DNA damage repair-proficient castrate-resistant prostate cancer to PARP inhibition

Author(s)Lawrence, Mitchell; Porter, Laura; Choo, Nicholas, et al
TypeJournal article
Date Published2021
Date Created-

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

Author(s)Khot, Amit; Brajanovski, Natalie; Cameron, Donald, et al
TypeJournal article
Date Published15-May-2019
Date Created-

High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology

Author(s)He, Jinshu; Soo, Priscilla; Evers, Maurits, et al
TypeJournal article
Date Published2018
Date Created-
TMP4886691142023717141313.pdf.jpg

A High-Throughput Screening Approach to Identify Therapeutics for the Treatment of Diamond-Blackfan Anaemia

Author(s)Núñez Villacís, Lorena; J Al-Obaidi, Sheren; Madhamshettiwar, Piyush, et al
TypeJournal article
Date Published2018
Date Created-
01_Hein_Inhibition_of_Pol_I_2017.pdf.jpg

Inhibition of Pol I Transcription a New Chance in the Fight Against Cancer

Author(s)Hein, Nadine; Hannan, Katherine; D'Rozario, James, et al
TypeJournal article
Date Published2017
Date Created-

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Author(s)Hein, Nadine; Cameron, Donald; Hannan, Katherine, et al
TypeJournal article
Date Published2017
Date Created-
s41467-019-12971-3.pdf.jpg

The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

Author(s)Liu, Pei Y.; Tee, Andrew E.; Milazzo, Giorgio, et al
TypeJournal article
Date Published2019
Date Created-
01_Shirokikh_Migration_of_Small_Ribosomal_2019.pdf.jpg

Migration of Small Ribosomal Subunits on the 5' Untranslated Regions of Capped Messenger RNA

Author(s)Shirokikh, Nikolay; Dutikova, Yulia S.; Staroverova, Maria A., et al
TypeJournal article
Date Published10-Sep-2019
Date Created-
1-s2.0-S0888754322001756-main.pdf.jpg

A new method for determining ribosomal DNA copy number shows differences between Saccharomyces cerevisiae populations

Author(s)Sharma, Diksha; Denmat, Sylvie Hermann-Le; Matzke, Nicholas J., et al
TypeJournal article
Date Published2022
Date Created-

Novel combination therapy targeting rDNA transcription and Histone Deacetylation Provides Effective Treatment for Multiple Myeloma, and Synergises in Bortezomib-Resistant MM

Author(s)MacLachlan, Kylee; Cuddihy, Andrew; Hein, Nadine, et al
TypeConference paper
Date Published29-Nov-2018
Date Created-
01_Somers_A_novel_small_molecule_that_2019.pdf.jpg

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Author(s)Somers, Klaartje; Wen, V. W.; Middlemiss, S. M. C., et al
TypeJournal article
Date Published22-Jan-2019
Date Created-

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