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Showing results 1 to 18 of 18

Abstract A24: A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer

Author(s)Yan, Shunfei; Chan, Keefe; Simpson, Kaylene J., et al
TypeJournal article
Date Published2017
Date Created-

Abstract B23: Inhibition of ribosomal RNA synthesis as a new therapeutic approach to treat advanced prostate cancer

Author(s)Rebello, Richard J; Kusnadi, Eric P.; Cameron, Donald, et al
TypeJournal article
Date Published2017
Date Created-

Abstract IA10: Drugging the ribosome at the level of synthesis and translation to treat solid and hematologic cancers

Author(s)Hannan, Ross; Hein, Nadine; Hannan, Kate, et al
TypeConference paper
Date Published2017
Date Created-

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Author(s)Hung, Sandy S.-C.; Lesmana, Analie; Peck, Abigail, et al
TypeJournal article
Date Published2017
Date Created-
01_Diesch_Changes_in_long-range_2019.pdf.jpg

Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation

Author(s)Diesch, Jeannine; Bywater, Megan J.; Sanij, Elaine, et al
TypeJournal article
Date Published28-Jan-2019
Date Created-

First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

Author(s)Khot, Amit; Brajanovski, Natalie; Cameron, Donald, et al
TypeJournal article
Date Published15-May-2019
Date Created-
01_Chan_A_functional_genetic_screen_2020.pdf.jpg

A functional genetic screen defines the AKT-induced senescence signaling network

Author(s)Chan, Keefe; Blake, Shaun; Zhu, Haoran, et al
TypeJournal article
Date Published2020
Date Created-

High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology

Author(s)He, Jinshu; Soo, Priscilla; Evers, Maurits, et al
TypeJournal article
Date Published2018
Date Created-
01_Hein_Inhibition_of_Pol_I_2017.pdf.jpg

Inhibition of Pol I Transcription a New Chance in the Fight Against Cancer

Author(s)Hein, Nadine; Hannan, Katherine; D'Rozario, James, et al
TypeJournal article
Date Published2017
Date Created-

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Author(s)Hein, Nadine; Cameron, Donald; Hannan, Katherine, et al
TypeJournal article
Date Published2017
Date Created-
01_Shirokikh_Migration_of_Small_Ribosomal_2019.pdf.jpg

Migration of Small Ribosomal Subunits on the 5' Untranslated Regions of Capped Messenger RNA

Author(s)Shirokikh, Nikolay; Dutikova, Yulia S.; Staroverova, Maria A., et al
TypeJournal article
Date Published10-Sep-2019
Date Created-

Novel combination therapy targeting rDNA transcription and Histone Deacetylation Provides Effective Treatment for Multiple Myeloma, and Synergises in Bortezomib-Resistant MM

Author(s)MacLachlan, Kylee; Cuddihy, Andrew; Hein, Nadine, et al
TypeConference paper
Date Published29-Nov-2018
Date Created-
01_Somers_A_novel_small_molecule_that_2019.pdf.jpg

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Author(s)Somers, Klaartje; Wen, V. W.; Middlemiss, S. M. C., et al
TypeJournal article
Date Published22-Jan-2019
Date Created-

Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance

Author(s)Martin, Claire. A; Cullinane, C; Kirby, Laura, et al
TypeJournal article
Date Published2018
Date Created-

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

Author(s)Lawrence, Mitchell; Obinata, Daisuke; Sandhu, Shahneen, et al
TypeJournal article
Date Published2018
Date Created-

RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest

Author(s)Hannan, Katherine; Kennedy, Brian K.; Cavanaugh, Alice H., et al
TypeJournal article
Date Published2000
Date Created-
01_Wagner_Selective_Translation_Complex_2020.pdf.jpg

Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes

Author(s)Wagner, Susan; Herrmannová, Anna; Hronová, Vladislava, et al
TypeJournal article
Date Published2020
Date Created-

Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC-Driven Cancer Progression

Author(s)Gao, Jixuan; Jung, MoonSun; Mayoh, Chelsea, et al
TypeJournal article
Date Published2020
Date Created-
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